Arabinogalactins, substances found in many plants, are long molecules made of the sugars galactose and arabinose linked together in a chain. Arabinogalactan extracted from the Western larch tree (larch arabinogalactan, or LA) has been proposed as an immune stimulant.
On the basis of these findings, LA has been advocated as a supplement for general immune support . However, this recommendation is premature. It is a very, very long way from basic science of this type to evidence that a treatment has real effectiveness. Many plant substances appear to activate the immune system; this may be merely because the immune system regards them as “the enemy,” and mobilizes to fight them. It takes double-blind, placebo-controlled trials to determine whether theoretical effects translate into real life benefits, and thus far only one such study has been performed on LA as an immune stimulant. Unfortunately, this single meaningful trial was not designed to determine the actual medical benefits (if any) of LA. Rather, it primarily continued the theoretical investigation of LA’s effects on components of the immune system.
One additional set of potential risks derives from its supposed benefits: If LA does in fact meaningfully stimulate the immune system, it might be dangerous. The immune system is balanced on a knife's edge. An immune system that is too relaxed fails to defend us from infections; an immune system that is too active attacks healthy tissues, causing autoimmune diseases. If LA truly boosts immunity, it might cause or worsen such conditions as lupus , Crohn’s disease , asthma , Graves’ disease , Hashimoto’s thyroiditis , multiple sclerosis , or rheumatoid arthritis , among other problems. In addition, people who take immune suppressant drugs for organ transplants would be at risk of organ rejection. However, there is no actual evidence that it causes problems.
Maximum safe doses in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
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- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012 -
- Update Date: 07/25/2012 -