Meta-analysis shows increased risk of cerebrovascular accident, ischemic heart disease
TUESDAY, Oct. 15 (HealthDay News) -- Inflammatory bowel disease (IBD) is associated with significantly increased risks of cerebrovascular accident (CVA) and ischemic heart disease (IHD), according to a review and meta-analysis presented at the annual meeting of the American College of Gastroenterology, held from Oct. 11 to 16 in San Diego.
Siddharth Singh, M.B.B.S., from the Mayo Clinic in Rochester, Minn., and colleagues reviewed the literature and conducted a meta-analysis of nine studies (2,424 CVA events in five studies and 6,478 IHD events in six studies) to examine the correlation between IBD and CVA, IHD, and extra-intestinal peripheral arterial thromboembolic disease.
The researchers found that the risk of CVA was significantly increased with IBD (five studies: odds ratio, 1.18), particularly in females and young adults. The increased risk of CVA was seen with Crohn's disease and ulcerative colitis. The risk of IHD was also significantly increased with IBD (six studies: odds ratio, 1.19), primarily in females, and was increased with Crohn's disease and ulcerative colitis. There was no significant correlation seen between IBD and the risk of peripheral arterial thromboembolic events.
"Gastroenterologists should be cognizant of this relationship and should focus on better management of conventional risk factors, such as smoking cessation, recognition and control of hypertension and diabetes," Singh said in a statement.
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